Which class of medications is commonly used in Duchenne cardiology management when indicated?

• A. Beta-blockers
• B. ACE inhibitors
• C. Calcium channel blockers
• D. Statins

Answer: (B)

In Duchenne cardiology, controlling the heart’s remodeling process is key. When the heart shows involvement or reduced function, blocking the renin-angiotensin system with an ACE inhibitor helps by lowering angiotensin II–driven vasoconstriction and aldosterone‑mediated fibrosis. This reduces afterload, slows adverse remodeling, and helps preserve or improve left‑ventricular function, which can translate to better outcomes and survival. That’s why this class is commonly used when indicated. Other options have roles in different contexts—beta-blockers can be beneficial but aren’t the standard first‑line in this specific scenario, calcium channel blockers may worsen heart failure by their stronger negative inotropic effects, and statins don’t address the cardiomyopathy seen in Duchenne.