LAMA2-related congenital muscular dystrophy is associated with what pattern on brain MRI?

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Multiple Choice

LAMA2-related congenital muscular dystrophy is associated with what pattern on brain MRI?

Explanation:
LAMA2-related congenital muscular dystrophy often shows white matter involvement on brain MRI, reflecting abnormalities in CNS myelination due to merosin (laminin-α2) deficiency. The pattern is diffuse, symmetric T2/FLAIR hyperintensity in the cerebral white matter, commonly around the periventricular areas, and can be seen in infancy. This white matter signal abnormality is a characteristic finding for this condition and helps distinguish it from a normal MRI or from patterns seen with other brain pathologies. The other options—normal brain MRI, cerebral microbleeds, or a brain tumor—do not fit the typical imaging pattern associated with LAMA2-related disease.

LAMA2-related congenital muscular dystrophy often shows white matter involvement on brain MRI, reflecting abnormalities in CNS myelination due to merosin (laminin-α2) deficiency. The pattern is diffuse, symmetric T2/FLAIR hyperintensity in the cerebral white matter, commonly around the periventricular areas, and can be seen in infancy. This white matter signal abnormality is a characteristic finding for this condition and helps distinguish it from a normal MRI or from patterns seen with other brain pathologies. The other options—normal brain MRI, cerebral microbleeds, or a brain tumor—do not fit the typical imaging pattern associated with LAMA2-related disease.

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